Inherited Bleeding Disorder-Hemophilia

Inherited Bleeding Disorder-Hemophilia | HealthFitness

A brief definition of Hemophilia:

It is a condition in which blood does not coagulate. Hemophilia is very rare and mainly affects men.

People with Hemophilia have asked for a lack of protein. Proteins work with platelet cells to stop bleeding at the site of the lesion. In Hemophilia a person bleeds a lot after the trauma. Bleeding can be fatal if it occurs in a vital organ such as the brain.

Signs and symptoms of Hemophilia

Signs and symptoms depending on the level of the coagulation factor. If it is simply reduced, it can bleed after an injury or surgery. If it is cut, you may have spontaneous bleeding.

Here are other symptoms

• Bleeding caused by injury or cuts or after dental surgery.
• Deep and wide bruises.
• Bleeding after vaccination
• Unexplained irritability in newborns.
• Nasal bleeding without cause.
• Blood in urine and faeces.
• Swelling, pain and tightness of the joints.

In severe Hemophilia, bleeding in the brain with the following signs and symptoms:

• Suitable or convulsions.
• Vision problem as double vision.
• Insomnia
• Excessive vomiting.
• Headache, painful and prolonged.
• Weakness.

Causes of Hemophilia:

A system of your body known as "the cascade of coagulation" normally stops bleeding. Blood platelets coagulate or collect at the site of the wound to form a clot. Then, the elements of body coagulation work together to create an extra spine in the wound. A low degree of these clotting factors or the absence of these reasons results in the continuation of bleeding. Hemophilia is a hereditary genetic disease, which means that it is transmitted by families. It is caused by a defect in the gene that determines how the body produces elements VIII, IX or XI. These genes are positioned on the X chromosome, making Hemophilia an X-linked recessive disease.

Each person inherits two sex chromosomes from his parents. Females have two X chromosomes. One X chromosome and one Y chromosome is in male.

Males inherit an X chromosome from the mother and a Y chromosome from the father. Females receive an X chromosome from each parent. Since the genetic defect that motivates Hemophilia is located on the X chromosome, fathers can not transmit the disease to their children. It is also the possibility that if a man has the X chromosome with the gene-modified by his mother, he will have Hemophilia. A woman with an X chromosome carrying the modified gene has a 50% chance of passing this gene to her children, men or women.

A woman who has the modified gene on one of her X chromosomes is commonly referred to as a "carrier". This means that he can also transmit the disturbance to his little ones, but he does not have the disorder alone. Indeed, its normal X chromosome contains many coagulation factors that prevent serious bleeding problems. However, surrogate girls are more likely to bleed.

Men with an X chromosome with the modified gene might also miss it in their daughters, making them vectors. A woman should have this modified gene on each of her X chromosomes to have Hemophilia. However, it is a very rare risk factor for Hemophilia inheritance.

Hemophiliacs A and B are particularly common in adult men compared to women because of genetic transmission.

Hemophilia C is an inherited autosomal structure of the disease, which means that it affects both men and women. This is due to the genetic defect that motivates this type of Hemophilia without any link to the sex chromosomes. According to the Indiana Hemophilia and Thrombosis Center, this disordered pattern typically affects humans of Ashkenazi Jewish origin, but may also affect other ethnic organizations.

Diagnosis of Hemophilia:

Hemophilia is recognized by a blood test. The doctor will remove a small stream of blood from the vein and measure the amount of coagulation component present. The model is then evaluated to determine the severity of the deficiency of the thing.

Mild haemophilia is considered a plasma clotting problem ranging from 5 to 40%.

Moderate Hemophilia is indicated by a plasma coagulation factor between 1 and 5%.

Severe Hemophilia is indicated by the resource of an aspect of coagulation in the plasma of a very bad, much less than 1%.

Treatment of Hemophilia:

The doctor can treat Hemophilia B by injecting donor blood clotting factors into the blood. Sometimes factors can also be given in the artificial form. These are called "recombinant coagulation factors".

Your doctor can treat Hemophilia C with a plasma infusion. The infusion acts to stop heavy bleeding. The weak problem responsible for Hemophilia C is only useful as a medicine in Europe. You can also apply to the physical remedy for rehabilitation if the joints are fractured by Hemophilia.

Prevent measures:

Hemophilia is a situation that has been overcome by a mother for her child. When you are pregnant, there is no way to know if your child is infected or not. However, if your eggs are fertilized in a medical facility by IVF, they can be tested. Thus, only eggs in addition to Hemophilia can be implanted. Pre-conception and prenatal counselling can also help you recognize the risk of having a child with Hemophilia.